Solving the Bioprocessing Cost Challenge

Our primary focus is tackling the critical barrier that limits patient access to medicine: the excessive cost of biologics.

Explore Our Technology

CORIg™: Continuous Centrifuge

Uniting forces to provide exceptional separation. True continuous separation with low shear.

CORIg-midi System

Why CORIg?

CORIg™ is the first single-use centrifuge with true continuous discharge and gentle cell handling. Its novel rotational liquid management technology enables runs of over 30 days and delivers a 4-8 fold improvement in throughput within a small footprint.

Key Features

  • High Recovery Without Shear: Typically achieves 95-99% cell recovery with unchanged viability.
  • Unmatched Versatility: Handles cultures from 0.1 million to >350 million cells/mL.
  • Smart: Fully automated with non-invasive turbidity and pressure sensors.

Automated Applications

CORIg Perfusion Workflow

Figure: CORIg Perfusion Workflow

  • Perfusion (P): Intelligent cell bleed minimizes liquid product loss.
  • Liquid Harvest (L): Efficiently recovers maximum product in liquid.
  • Solids/Cells Concentration and Washing (S-B): Concentration and washing of cells.

CORIg-midi Technical Specifications

Functional Specifications
Max Centrifugal Force2000g
Typical Process Flow Rate80-150 L/hr
Inlet Cell Density0.05-350 X 106 cells/mL
Max Outlet Cell Density400 X 106 cells/mL
Physical & Utility Specs
Floor Space54.5 cm X 50.0 cm (2.93 sq ft)
Height (Closed)122.5 cm
Supply Voltage100-250 VAC
Instrument Air>60 psi

machroS™: Purification Without Clarification

A revolutionary single-use chromatography platform that enables direct capture from crude, unclarified materials.

Eliminate the Clarification Train

machroS™ eliminates the need for primary and secondary clarification steps, allowing direct purification from high-density, low-viability cultures (>30000 NTU) or whole blood.

Simplified Process Flow:
  1. Mix crude, unclarified material with machroS media.
  2. System captures target bound to machroS media and discards unbound material.
  3. Wash and Elute product.
machroS-mini System

How It Works

The platform uses non-porous, chemically-defined nanoparticles to achieve extremely fast mass transfer.

  • Ultrafast Kinetics: Over 90% of the product binds in less than 30 seconds.
  • Rapid Cycling: Completes 100 cycles in one day, making the media economically viable for single-batch use.
  • Versatile Ligands: Includes Protein A, AEX, Oligo(dT), and AAV/Lenti-specific ligands.

Dramatic Cost & Time Reduction

  • 81% cost reduction per gram of mAb.
  • 76% cost reduction per batch.
  • Saves 42 hours of total time per batch.

machroS™ Discovery Kit

Validate Direct Capture in Your Lab

Experience the power of purification without clarification with machroS-ProA. Leveraging Protein A, the industry-standard ligand for mAb capture, the Discovery Kit allows you to purify 0.5 grams of mAb in 10 minutes (one cycle) by processing small volumes of crude cell culture directly—bypassing centrifugation and filtration.

Accelerate Your Workflow:

  • ✓
    Early Discovery: Rapidly purify and screen different mAbs from multiple clones.
  • ✓
    Cell Line Development (CLD): Isolate mAbs quickly for analytical tests.
  • ✓
    Process Development (PD): Check the impact of change in upstream process parameters in near real-time.

Interested in the Kit?

We are currently updating our online ordering system.

To order the machroS Discovery Kit or for pricing inquiries, please get in touch with our team directly.

Contact Us to Order
cRUSH System

cRUSH™: Continuous Homogenizer

The first single-use, continuous-flow mechanical system designed for cell lysis of microbial and mammalian cells.

Key Advantages

  • Superior Efficiency: Delivers 3-7 times greater lysis efficiency than detergent methods.
  • AAV Performance: Showed a 471% improvement over Triton detergent.
  • Detergent-Free: Operates without chemicals, critical for EU compliance.
  • Tunable: Provides complete control of lysis/homogenization for sensitive biologics.

Applications & Solutions

Transforming bioprocessing from Process Development to Commercial Manufacturing.

Cell & Gene Therapy (CGT)

Challenges: Fragile cells, washing, high concentrated cell density, research-grade processes, viral vectors being larger than pores of porous chromatography and long processing times make workflows difficult to scale.
The AthemBio Solution:
  • CORIg: Gentle concentration and washing (low shear).
  • cRUSH: Scalable, detergent-free lysis.
  • machroS: Direct affinity capture of viral vectors.

Monoclonal Antibodies (mAbs)

Challenges: Cell retention systems not capable of handling high cell densities and causing significant bleed losses. Clarification steps slow down production, increase cost, and risk product loss. Product loss from product trapped in slurry.
The AthemBio Solution:
  • ProA-machroS: Direct mAb capture from cell culture (<30s binding).
  • CORIg: Ultra high cell density perfusion with minimal loss from bleed. Continuous high-speed clarification.

Vaccines & Viral Vectors

Challenges: High shear homogenizers damage large viral particles; porous chromatography utilizes ligands on the surface only; infected cells are shear sensitive.
The AthemBio Solution:
  • cRUSH: Detergent-free effective cell lysis solution that keeps viruses intact.
  • machroS: Nonporous resin provides exteremely large effective surface area for purification of viral veactors.
  • CORIg: Versatile for intracellular and extracellular viruses. Efficient concentration and washing or recovery of supernatant.

Who We Are

At AthemBio, we are solving the toughest challenges in bioprocessing. Far too many promising therapies are discontinued due to high manufacturing expenses. We are a private company in Research Triangle Park, NC, on a mission to make advanced therapies accessible to all.

We provide innovative, next-generation platforms that are continuous and have a significantly smaller footprint.

Our Design Philosophy

To be truly next-generation, every solution must be built on core principles:

  • Automated & Continuous: Reduces steps & replaces intermittent processes.
  • Non-Invasive Sensing: Real-time monitoring & reduces cost of assemblies.
  • Efficient & Compact: Max throughput per sq. ft.
  • Single-Use & Closed: Eliminates cleaning downtime & cross-contamination.

Next-Generation Bioprocessing

Our solution lies in groundbreaking, single-use technologies that:

Reduce manufacturing steps
Enable manufacturing of challenging materials
Significantly lower overall costs

Our Leadership

Sunil Mehta, Ph.D.

Sunil Mehta, Ph.D.

CEO

Dr. Sunil Mehta is a scientist, inventor, and global entrepreneur with a 25-year record of success in biopharmaceuticals and cGMP manufacturing. His deep expertise in the entire bioprocessing workflow, honed at global leaders like Johnson & Johnson, Roche, KBI Biopharma, and Sartorius, guides AthemBio's mission. As a proven entrepreneur, Dr. Mehta co-founded kSep Systems and led its remarkable global growth and successful 2016 acquisition by Sartorius Stedim Biotech. He holds a Ph.D. from Brown University.

Mutiara Rusly

Mutiara Rusly

President

As President of AthemBio, Mutiara Rusly (Muti) draws on more than two decades of management experience across a range of industries. A graduate of Baruch College with a degree in accounting, her career includes key roles at Vanguard and Avenue A Razorfish. She oversees operations and ensures the company's strategic vision is executed efficiently.

Rob Schwartzman

Rob Schwartzman

IP Counsel

Rob Schwartzman serves as IP Counsel for AthemBio, where he manages the company's global patent portfolio and strategy. He brings a unique blend of scientific and legal expertise, holding a Ph.D. in pharmacology from UNC-Chapel Hill and a J.D. from Georgetown. He previously served for six years as an examiner at the United States Patent and Trademark Office.

Get in Touch

We work side-by-side with our customers through all stages: Early Process Development, Scale-Up, and Commercial Manufacturing.

Contact Information

AthemBio
2 Davis Drive, Durham, NC 27709, USA
Phone: +1-919-339-1850
Email: info@athembio.com

Send us a Message

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Process Legend
Cell Culture (Liquid)
Cells (Impurities)
machroS Nanoparticles
Antibodies (mAbs)
Wash Buffer
Elution Buffer
Retention System